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Immunoperoxidase Technique for Detecting Spirochetes in Tissue Sections: Comparison with Other Methods by Robert George Phelps; Jeffrey Knispel; Erik Schuman Tu; Georgetta Cernainu; Michael Saruk is a Medicine article available to read on EtoBox.
What is Immunoperoxidase Technique for Detecting Spirochetes in Tissue Sections: Comparison with Other Methods about?
**Abstract** **Background** With the increasing incidence of human immunodeficiency virus (HIV) infection and immunosuppressive therapy, the incidence of syphilis has been increasing. Given the fact that the above conditions may mask or obscure the usual clinical signs and symptoms of syphilis, a means of enhanced detection is essential. **Aims methods** The purpose of this study was to determine whether an immunoperoxidase method using an antibody against treponemes would increase the sensitivity and specificity of diagnosis in biopsies of patients with secondary syphilis. This was compared to serology and silver stain in cases of known syphilis. **Results** Immunoperoxidase for treponemes was at least as sensitive (9/10) as pathology (9/10), and more sensitive than conventional silver stain (6/10) or serology (7/10). **Conclusions** In those equivocal cases of secondary syphilis, where confirmation is essential, immunoperoxidase for treponemes may be a useful adjunct.
Who reads Immunoperoxidase Technique for Detecting Spirochetes in Tissue Sections: Comparison with Other Methods?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Robert George Phelps; Jeffrey Knispel; Erik Schuman Tu; Georgetta Cernainu; Michael Saruk
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0011-9059)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)