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Can I read CD47 Overexpression Is Associated with Epstein–Barr Virus Infection and Poor Prognosis in Patients with Nasopharyngeal Carcinoma on EtoBox?
CD47 Overexpression Is Associated with Epstein–Barr Virus Infection and Poor Prognosis in Patients with Nasopharyngeal Carcinoma by Zhi-Hui Wang; Xiao-Feng Pei; Zhi-Quan Zhu; Zhong Lin; Yin-Yan Mao; Xiao-Lu Xu; You-Li Luo; Li Zhang; Pei-Jian Peng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is CD47 Overexpression Is Associated with Epstein–Barr Virus Infection and Poor Prognosis in Patients with Nasopharyngeal Carcinoma about?
## Purpose Little is known about the clinical significance of CD47 expression and its association with Epstein–Barr virus (EBV) infection in patients with nasopharyngeal carcinoma (NPC). The aim of this study was to clarify the prognostic value and role of CD47 in EBV-associated NPC. ## Materials and Methods Sixty-six cases of non-metastatic NPC were retrospectively reviewed. Tissues were collected for immunohistochemical staining of CD47 and the EBV-encoded oncoprotein latent membrane protein 1 (LMP1). Western blotting and quantitative real-time PCR were performed to determine the CD47 and LMP1 levels in common human NPC cell lines. Additionally, CD47 and LMP1 expression in a constructed EBV-positive human NPC cell (CNE-2-EBV+) and a stable cell line transfected with LMP1 plasmid (CNE-2-LMP1) was assessed. Next, we used Western blotting to assess the decrease in CD47 expression on CNE-2-LMP1 cells after transfecting them with small interfering RNA (siRNA)-targeting LMP1. ## Results In NPC patients, CD47 overexpression was significantly associated with disease recurrence (__P__=0.010), leading to poorer disease-free survival (DFS; __P__=0.002) and overall survival (__P__=0.021). Mu
Who reads CD47 Overexpression Is Associated with Epstein–Barr Virus Infection and Poor Prognosis in Patients with Nasopharyngeal Carcinoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zhi-Hui Wang; Xiao-Feng Pei; Zhi-Quan Zhu; Zhong Lin; Yin-Yan Mao; Xiao-Lu Xu; You-Li Luo; Li Zhang; Pei-Jian Peng
- Publisher
- Informa UK Limited
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)