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Can I read Factors predicting survival following alloSCT in patients with therapy-related AML and MDS: a multicenter study on EtoBox?
Factors predicting survival following alloSCT in patients with therapy-related AML and MDS: a multicenter study by Anmol Baranwal; Rakchha Chhetri; David Yeung; Matthew Clark; Syed Shah; Mark R. Litzow; William J. Hogan; Abhishek Mangaonkar; Hassan B. Alkhateeb; Deepak Singhal; Alia Cibich; Peter Bardy; Chung H. Kok; Devendra K. Hiwase; Mithun Vinod Shah is a Medicine article available to read on EtoBox.
What is Factors predicting survival following alloSCT in patients with therapy-related AML and MDS: a multicenter study about?
Therapy-related myeloid neoplasms (t-MN) are aggressive myeloid neoplasms. Factors predicting post-allogeneic stem cell transplant (alloSCT) survival are not well-known. We studied the prognostic utility of factors at: t-MN diagnosis, pre-alloSCT, and post-alloSCT. Primary endpoints were 3-year overall survival (OS), relapse incidence (RI), and non-relapse mortality (NRM). Post-alloSCT OS did not differ between t-MDS and t-AML (20.1 vs. 19.6 months, P = 1), though t-MDS had a significantly higher 3-year RI compared to t-AML (45.1% vs. 26.9%, P = 0.03). In t-MDS, the presence of monosomy 5 (HR 3.63, P = 0.006) or monosomy 17 (HR 11.81, P = 0.01) pre-alloSCT were associated with higher RI. Complex karyotype was the only factor adversely influencing survival at all the timepoints. The inclusion of genetic information yielded 2 risk-categories: high-risk defined by the presence of pathogenic variants (PV) in (TP53/BCOR/IDH1/GATA2/BCORL1) and standard-risk (remainder of the patients) with 3-year post-alloSCT OS of 0% and 64.6%, respectively (P = 0.001). We concluded that while alloSCT was curative in a subset of t-MN patients, outcomes remained poor, specifically in the high-risk catego
Who reads Factors predicting survival following alloSCT in patients with therapy-related AML and MDS: a multicenter study?
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- Author
- Anmol Baranwal; Rakchha Chhetri; David Yeung; Matthew Clark; Syed Shah; Mark R. Litzow; William J. Hogan; Abhishek Mangaonkar; Hassan B. Alkhateeb; Deepak Singhal; Alia Cibich; Peter Bardy; Chung H. Kok; Devendra K. Hiwase; Mithun Vinod Shah
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)