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Expression of Stress-induced MHC Class I Related Chain Molecules on Human Melanoma by Claudia S. Vetter; Veronika Groh; Per thor Straten; Thomas Spies; Eva-B Bröcker; Jürgen C. Becker is a Medicine article available to read on EtoBox.

What is Expression of Stress-induced MHC Class I Related Chain Molecules on Human Melanoma about?

Cellular immune responses to melanoma are tightly regulated and include specific T cell responses to self antigens such as Mart-1 and gp100. Thus, additional signals apart from those mediated by the T cell receptor are needed to ensure T cell activation. Recently, the stress inducible major histocompatibility complex molecules, MHC class I related chain, were identified as an activator of both natural killer and T cells via interaction with their receptor NKG2D. Herein, we report the expression of MIC in 31 of 40 primary cutaneous melanomas and in 13 of 20 metastatic lesions. Moreover, lymphocytes infiltrating the tumor were found to express NKG2D. Detailed analysis identified both CD3+ T cells as well as CD56+ natural killer cells contributing to this NKG2D+ tumor infiltrating lymphocyte population present.

Who reads Expression of Stress-induced MHC Class I Related Chain Molecules on Human Melanoma?

Author

Claudia S. Vetter; Veronika Groh; Per thor Straten; Thomas Spies; Eva-B Bröcker; Jürgen C. Becker

Publisher

Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; Springer Science and Business Media LLC; Wiley (ISSN 0022-202X)

Published

2002

Language

EN

Field

Medicine (Health Sciences)