Can I read Neural Basis of Transcutaneous Electrical Nerve Stimulation for Neuropathic Pain Relief on EtoBox?

Neural Basis of Transcutaneous Electrical Nerve Stimulation for Neuropathic Pain Relief by Shuai Liu & Sha-Sha Long & Fanfei Li & Huan Yang & Shaofeng Pu & Dongping Du & Xin Luo & Yu-Qiu Zhang & Qingjian Han is a book available to read on EtoBox.

What is Neural Basis of Transcutaneous Electrical Nerve Stimulation for Neuropathic Pain Relief about?

Neuron, Corrected proof. doi:10.1016/j.neuron.2025.08.010SUMMARYExisting treatments for chronic pain often prove ineffective and carry adverse side effects, highlighting theneed for better analgesics, including non-pharmacological treatments. We demonstrate that transcutaneous electrical nerve stimulation (TENS), when repeatedly applied during the early phase of nerve injuryin mice, produces sustained analgesic effects by activating the dorsal column nucleus (DCN)-thalamiccortical pathway, which transmits vibration, discriminative touch, and proprioception. Mechanistically,TENS selectively activates glutamatergic neurons in the DCN (DCNGlu) via exciting Aβ low-threshold mechanoreceptors (Aβ-LTMRs) in dorsal root ganglia (DRGs). These DCNGlu neurons project to a distinct subsetof glutamatergic neurons in the thalamic ventral posterolateral nucleus (VPLDCN, Glu), separate from neuronsreceiving spinal dorsal horn input (VPLSDH, Glu). VPLDCN, Glu neurons form monosynaptic connections withlayer 5 neurons in the somatosensory hindlimb cortex (S1HL), mediating TENS-induced analgesia. Our findings disclosed a neural basis of TENS-mediated pain relief and offered a promising therapeutic

Author

Shuai Liu & Sha-Sha Long & Fanfei Li & Huan Yang & Shaofeng Pu & Dongping Du & Xin Luo & Yu-Qiu Zhang & Qingjian Han

Publisher

x

Published

2025

Language

EN