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Steroid Receptor Coactivator 3 Regulates Synaptic Plasticity and Hippocampus-dependent Memory by Hai-Long Zhang; Bing Zhao; Pin Yang; Yin-Quan Du; Wei Han; Jianming Xu; Dong-Min Yin is a Neuroscience article available to read on EtoBox.

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## Abstract Steroid hormones play important roles in brain development and function. The signaling of steroid hormones depends on the interaction between steroid receptors and their coactivators. Although the function of steroid receptor coactivators has been extensively studied in other tissues, their functions in the central nervous system are less well investigated. In this study, we addressed the function of steroid receptor coactivator 3 (SRC3) – a member of the p160 SRC protein family that is expressed predominantly in the hippocampus. While hippocampal development was not altered in Src3^+/−^ mice, hippocampus-dependent functions such as short-term memory and spatial memory were impaired. We further demonstrated that the deficient learning and memory in Src3^+/−^ mice was strongly associated with the impairment of long-term potentiation (LTP) at Schaffer Collateral-CA1 synapses. Mechanistic studies indicated that Src3^+/−^ mutation altered the composition of N-methyl-D-aspartate receptor subunits in the postsynaptic densities of hippocampal neurons. Finally, we showed that SRC3 regulated synaptic plasticity and learning mainly dependent on its lysine acetyltransferase activi

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Author

Hai-Long Zhang; Bing Zhao; Pin Yang; Yin-Quan Du; Wei Han; Jianming Xu; Dong-Min Yin

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)