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Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy by Annink, Kim V. (author);de Vries, Linda S. (author);Groenendaal, Floris (author);Eijsermans, Rian M. J. C. (author);Mocking, Manouk (author);van Schooneveld, Monique M. J. (author);Dudink, Jeroen (author);van Straaten, Henrica L. M. (author);Benders, Manon J. N. L. (author);Lequin, Maarten (author);van der Aa, Niek E. (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopmental outcome in 10-year-old children with HIE with and without therapeutic hypothermia. Additional aims were to assess the associations between MB atrophy, brain volumes (including the hippocampi), white matter microstructure and neurodevelopmental outcome at school-age. Ten-year-old children with HIE were included, who were treated with therapeutic hypothermia (n = 22) or would have qualified but were born before this became standard of care (n = 28). Children completed a neuropsychological and motor assessment and MRI. Mammillary bodies were scored as normal or atrophic at 10 years. Brain volumes were segmented on childhood MRI and DTI scans were analysed using tract-based spatial statistics. Children with HIE suffered from neurocognitive and memory problems at school-age, irrespective of hypothermia. Hippocampal volumes and MB atrophy were associated with total and performance IQ, processing speed and episodic memory in both groups. Normal MB and larger hippocampi

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Author

Annink, Kim V. (author);de Vries, Linda S. (author);Groenendaal, Floris (author);Eijsermans, Rian M. J. C. (author);Mocking, Manouk (author);van Schooneveld, Monique M. J. (author);Dudink, Jeroen (author);van Straaten, Henrica L. M. (author);Benders, Manon J. N. L. (author);Lequin, Maarten (author);van der Aa, Niek E. (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)