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Non-adaptive cellular immune responses as studied in euthymic and athymic nude rats: Spontaneous rejection of allogeneic lymphoid cell grafts by natural killer (NK) cells by Bent Rolstad; Sigbjrn Fossum is a Neuroscience article available to read on EtoBox.

What is Non-adaptive cellular immune responses as studied in euthymic and athymic nude rats: Spontaneous rejection of allogeneic lymphoid cell grafts by natural killer (NK) cells about?

The athymic nude (rnu) rat lacks a functional thymus and normal alloreactive T cells. These animals, therefore, have been widely used as tools for studying thymus-independent immune responses. The absence of functional T cells would, to most investigators, indicate that these rats have a defective cellular immune defence. However, although rnu rats accept organ allografts infinitely, they are nevertheless capable of rejecting allografts consisting of lymphocytes or bone marrow cells with increased vigour, and this via antibody-independent mechanisms. These rejection phenomena have operationally been termed allogeneic lymphocyte cytotoxicity (ALC) and allogeneic bone marrow cell cytotoxicity (ABC). Unlike organ allograft immunity this kind of rejection requires no presensitization of the recipient and is surprisingly rapid: it commences within a few hours of i.v. injection of the allogeneic cells and is usually complete by 24 h. Moreover, products coded for by genes within, or closely linked to the major histocompatibility complex (MHC), are clearly involved in the interaction between effector and target cells, as grafted cells from MHC-congenic rat strains are vigorously rejected.

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Author

Bent Rolstad; Sigbjrn Fossum

Publisher

Springer; Springer-Verlag; Springer Verlag; J.F. Bergmann; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-2061)

Published

1990

Language

EN

Field

Neuroscience (Life Sciences)