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Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk by Bao‐li Chang; Siqun L. Zheng; Sarah D. Isaacs; Aubrey Turner; Gregory A. Hawkins; Kathy E. Wiley; Eugene R. Bleecker; Patrick C. Walsh; Deborah A. Meyers; William B. Isaacs; Jianfeng Xu is a Medicine article available to read on EtoBox.
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## Abstract CYP1A1 is likely to play an important role in the etiology of CaP through its function in activating environmental procarcinogens and catalyzing the oxidative metabolites of estrogens. To test the hypothesis that genetic polymorphisms in the __CYP1A1__ gene may be associated with the risk for CaP, we compared the allele, genotype and haplotype frequencies of 3 SNPs (3801T>C, 2455A>G and 2453C>A) of __CYP1A1__ among 159 HPC probands, 245 sporadic CaP cases and 222 unaffected men. Two SNPs (3801T>C and 2455A>G) were each individually associated with CaP risk when the allele and genotype frequencies were compared between CaP patients and unaffected controls. Furthermore, a combined SNP analysis using a haplotype approach revealed an even stronger association in Caucasians. Specifically, 4 major haplotypes (T‐A‐C, C‐A‐C, C‐G‐C and T‐A‐A) accounted for 99.8% of all observed haplotypes. These 4 haplotypes correspond to the previously described nomenclature (__CYP1A1__\*1A, __CYP1A1__\*2A, __CYP1A1__\*2B and __CYP1A1__\*4). The frequencies of these 4 haplotypes were significantly different among CaP patients and controls. The haplotype T‐A‐C (__CYP1A1__\*1A) was significantly
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- Author
- Bao‐li Chang; Siqun L. Zheng; Sarah D. Isaacs; Aubrey Turner; Gregory A. Hawkins; Kathy E. Wiley; Eugene R. Bleecker; Patrick C. Walsh; Deborah A. Meyers; William B. Isaacs; Jianfeng Xu
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)