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Apoptosis Is Involved in the Cardiac Damage Induced by Sinoaortic Denervation in Rats by Xia Tao; Shu‐Hui Zhang; Zheng‐Xu Chu; Ding‐Feng Su is a Medicine article available to read on EtoBox.

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## Summary 1. The arterial baroreflex plays an important role in the maintenance of the stability of blood pressure. Sinoaortic denervation (SAD) produces severe organ damage in rats. The present study was designed to investigate whether apoptosis, which is a ubiquitous physiological mode of cell death distinct from cell mortality induced by injury and necrosis, is involved in SAD‐induced cardiac damage. 2. Male Sprague‐Dawley rats (10 weeks old) were used. Rats underwent SAD (__n__ = 9) or sham operation (__n__ = 10). Sixteen weeks after operation, the heart tissues were taken for investigations including electron microscopy, immunohistochemistry, terminal deoxynucleotidyl transferase (TdT)‐mediated dUTP nick‐end labelling (TUNEL) and reverse transcription–polymerase chain reaction (RT‐PCR). 3. Cardiac hypertrophy and fibrosis was found in SAD rats. The number apoptotic cardiomyocytes was increased in SAD rats compared with sham‐operated rats. 4. The expression of Bcl‐2mRNA and protein (an inhibitory factor of apoptosis) in cardiomyocytes was decreased in SAD rats. In contrast, the expression of Bax, Fas and Fas ligand mRNA and proteins (promoters of apoptosis) in cardiomyocytes w

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Author

Xia Tao; Shu‐Hui Zhang; Zheng‐Xu Chu; Ding‐Feng Su

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0305-1870)

Published

2003

Language

EN

Field

Medicine (Health Sciences)