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Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients by Angela Genchi; Aurora Semerano; Ghil Schwarz; Beatrice Dell’Acqua; Giorgia Serena Gullotta; Michela Sampaolo; Enzo Boeri; Angelo Quattrini; Francesca Sanvito; Susanna Diamanti; Andrea Bergamaschi; Stefano Grassi; Paola Podini; Pietro Panni; Caterina Michelozzi; Franco Simionato; Francesco Scomazzoni; Paolo Remida; Luca Valvassori; Andrea Falini; Carlo Ferrarese; Patrik Michel; Guillaume Saliou; Steven Hajdu; Simone Beretta; Luisa Roveri; Massimo Filippi; Davide Strambo; Gianvito Martino; Marco Bacigaluppi is a Medicine article available to read on EtoBox.

What is Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients about?

## Abstract Coronavirus disease 2019 (COVID-19) is associated with an increased risk of thrombotic events. Ischemic stroke in COVID-19 patients entails high severity and mortality rates. Here we aimed to analyze cerebral thrombi of COVID-19 patients with large vessel occlusion (LVO) acute ischemic stroke to expose molecular evidence for SARS-CoV-2 in the thrombus and to unravel any peculiar immune-thrombotic features. We conducted a systematic pathological analysis of cerebral thrombi retrieved by endovascular thrombectomy in patients with LVO stroke infected with COVID-19 (n = 7 patients) and non-covid LVO controls (n = 23). In thrombi of COVID-19 patients, the SARS-CoV-2 docking receptor ACE2 was mainly expressed in monocytes/macrophages and showed higher expression levels compared to controls. Using polymerase chain reaction and sequencing, we detected SARS-CoV-2 Clade20A, in the thrombus of one COVID-19 patient. Comparing thrombus composition of COVID-19 and control patients, we noted no overt differences in terms of red blood cells, fibrin, neutrophil extracellular traps (NETs), von Willebrand Factor (vWF), platelets and complement complex C5b-9. However, thrombi of COVID-19 p

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Author

Angela Genchi; Aurora Semerano; Ghil Schwarz; Beatrice Dell’Acqua; Giorgia Serena Gullotta; Michela Sampaolo; Enzo Boeri; Angelo Quattrini; Francesca Sanvito; Susanna Diamanti; Andrea Bergamaschi; Stefano Grassi; Paola Podini; Pietro Panni; Caterina Michelozzi; Franco Simionato; Francesco Scomazzoni; Paolo Remida; Luca Valvassori; Andrea Falini; Carlo Ferrarese; Patrik Michel; Guillaume Saliou; Steven Hajdu; Simone Beretta; Luisa Roveri; Massimo Filippi; Davide Strambo; Gianvito Martino; Marco Bacigaluppi

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)