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Grapefruit Juice Effects on Drug Metabolism by Sadia Dipa is a document available to read on EtoBox.
What is Grapefruit Juice Effects on Drug Metabolism about?
1) Grapefruit juice interacts with certain drugs by inhibiting the intestinal enzyme CYP3A4, preventing their breakdown and increasing their bioavailability. 2) The furanocoumarins in grapefruit juice, particularly 6,7-dihydroxybergamottin, are responsible for this interaction by irreversibly inactivating CYP3A4 and accelerating its degradation. 3) Removing the furanocoumarins from grapefruit juice through filtration and chromatography eliminates its ability to interact with drugs metabolized by CYP3A4, as
- Author
- Sadia Dipa
- Language
- EN