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Prevalence of persistent and latent viruses in untreated patients infected with HIV-1 from Ghana, West Africa by Lara Isobel Compston; Chengyao Li; Francis Sarkodie; Shirley Owusu-Ofori; Ohene Opare-Sem; Jean-Pierre Allain is a Medicine article available to read on EtoBox.

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## Abstract Only limited epidemiological data, pertaining to the prevalence of common persistent viruses has been reported in Ghana. This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV‐1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV‐negative blood donors, asymptomatic HIV and symptomatic/AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus‐C (GBV‐C), cytomegalovirus (CMV), Epstein–Barr virus (EBV), human herpesvirus‐8 (HHV‐8) and varicella‐zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any group. Prevalence of GBV‐C plasma viraemia was significantly higher in asymptomatic and symptomatic HIV infection (16.7%) and (16.2%) than in blood donors (4%) __P__ < 0.005. Occult HBV infection was significantly more frequent in symptomatic HIV infection (10.9%) compared to asymptomatic HIV (3.6%) and blood donors (1.6%) __P__ < 0.005. Although there was a high background of EBV viraemia in cellular fractions of blood donors (8.3%

Who reads Prevalence of persistent and latent viruses in untreated patients infected with HIV-1 from Ghana, West Africa?

Author

Lara Isobel Compston; Chengyao Li; Francis Sarkodie; Shirley Owusu-Ofori; Ohene Opare-Sem; Jean-Pierre Allain

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

2009

Language

EN

Field

Medicine (Health Sciences)