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Association Between Fatigue and Failure to Preserve Cerebral Energy Turnover During Prolonged Exercise by L. Nybo; K. Møller; B. K. Pedersen; B. Nielsen; N. H. Secher is a Medicine article available to read on EtoBox.

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## Abstract **Aim:** This study evaluated if the fatigue and apathy arising during exercise with hypoglycaemia could relate to a lowering of the cerebral metabolic rates of glucose and oxygen. **Methods and results:** Six males completed 3 h of cycling with or without glucose supplementation in random order. Cerebral blood flow, metabolism and interleukin‐6 (IL‐6) release were evaluated with the Kety–Schmidt technique. Blood glucose was maintained during the glucose trial, while it decreased from 5.2 ± 0.1 to 2.9 ± 0.3 mmol L^−1^ (mean ± SE) after 180 min of exercise in the placebo trial with a concomitant increase in perceived exertion (__P__ < 0.05). During hypoglycaemia, the cerebral glucose uptake was reduced from 0.34 ± 0.05 to 0.28 ± 0.04 __μ__mol g^−1^ min^−1^, while the cerebral uptake of __β__‐hydroxybutyrate increased to 5 ± 1 pmol g^−1^ min^−1^ (__P__ < 0.05). The reduced glucose uptake was accompanied by a lowering of the cerebral metabolic rate of oxygen from 1.84 ± 0.19 mmol g^−1^ min^−1^ during exercise with glucose supplementation to 1.60 ± 0.16 mmol g^−1^ min^−1^ during hypoglycaemia (__P__ < 0.05). In addition, the cerebral IL‐6 release was reduced from 0.4 ± 0.1

Who reads Association Between Fatigue and Failure to Preserve Cerebral Energy Turnover During Prolonged Exercise?

Author

L. Nybo; K. Møller; B. K. Pedersen; B. Nielsen; N. H. Secher

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-6772)

Published

2003

Language

EN

Field

Medicine (Life Sciences)