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Increased Myocardial Extracellular Volume Is Associated with Myocardial Iron Overload and Heart Failure in Thalassemia Major by Antonella Meloni; Laura Pistoia; Vincenzo Positano; Antonio De Luca; Nicola Martini; Anna Spasiano; Ilaria Fotzi; Pier Paolo Bitti; Domenico Visceglie; Gianna Alberini; Gianfranco Sinagra; Alessia Pepe; Filippo Cademartiri is a Medicine article available to read on EtoBox.
What is Increased Myocardial Extracellular Volume Is Associated with Myocardial Iron Overload and Heart Failure in Thalassemia Major about?
## Objectives: Myocardial extracellular volume (ecv) by cardiovascular magnetic resonance (cmr) is a surrogate marker of diffuse fibrosis. we evaluated the association between ecv and demographics, cmr findings, and cardiac involvement in patients with thalassemia major (tm). ## Methods: A total of 108 β-tm patients (62 females, 40.16 ± 8.83 years), consecutively enrolled in the extension-myocardial iron overload in thalassemia network, and 16 healthy subjects (6 females, 37.12 ± 16.13 years) underwent cmr. the protocol included assessment of t2\*, native t1, and t2 values in all 16 myocardial segments for myocardial iron overload (mio) quantification, cine images for left ventricular (lv) function quantification, post-contrast t1 mapping for ecv calculation, and late gadolinium enhancement (lge) technique for replacement myocardial fibrosis detection. ## Results: Global ecv values were significantly higher in females than in males. global ecv values were significantly higher in patients with significant mio (global heart t2\* < 20 ms) than in patients without significant mio, and both groups exhibited higher global ecv values than healthy subjects. no association was detected betw
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- Author
- Antonella Meloni; Laura Pistoia; Vincenzo Positano; Antonio De Luca; Nicola Martini; Anna Spasiano; Ilaria Fotzi; Pier Paolo Bitti; Domenico Visceglie; Gianna Alberini; Gianfranco Sinagra; Alessia Pepe; Filippo Cademartiri
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)