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Separation of iodinated compounds of l-tyrosyl-l-tyrosine from iodothyronines by Biogel P-2 column chromatography by J. Michelot; D. Godeneche; J.C. Maurizis; G. Meyniel is a Chemistry article available to read on EtoBox.

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Previous investigations conducted in our laboratory have shown that the sequence Myrosyl-L-tyrosine is part of the primary structure of thyroglobulin. The dipeptide 3,5,3'S'-tetraiodo-L-tyrosyl-Myrosine (I,Tyr-I,Tyr) extracted from trypsic digests of bovine tbyroglobulinL Eras demonstrated the presence of this iodinated sequence under physiological conditions. In vitro experiments showed that this dipeptide is a better substrate than diiodotyrosine for the synthesis of iodothyronin&, and we proposed a mechanism of this synthesis which appealed to a cyclic agent without breaking the peptide bond 3\*4\_ During these in V&O experiments, we developed a new tfxbique for the separation of the iodinated compounds of tyrosyl-tyrosine from the known iodoamino acids\_ Various methods for the separation of iodo compounds have already been described: paper chromatography, &in-Bayer cbromatogrqhy, ionexchange cohmm chromatography, Sephadex gel filtration and gas-liquid chromatographys-lo. Up to 1975 no procedure allowing a complete separation of ali the known iocl oamino acids was available. Since 1975, following the work of Thomopoulos", we have been using a single Biogel P-2 column which sepa

Who reads Separation of iodinated compounds of l-tyrosyl-l-tyrosine from iodothyronines by Biogel P-2 column chromatography?

Author

J. Michelot; D. Godeneche; J.C. Maurizis; G. Meyniel

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

1980

Language

EN

Field

Chemistry (Physical Sciences)