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The cell biology of apoptosis: Evidence for the implication of mitochondria by S. A. Susin; N. Zamzami; G. Kroemer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The apoptotic process can be subdivided into three phases: a death-stimulus-dependent heterogeneous induction phase, a common effector phase during which the central apoptotic executioner is activated, and a common degradation phase during which cells acquire the biochemical and morphological features of end-stage apoptosis. Recently, it has become clear that the central apoptosis executioner is dictated by cytoplasmic (non-nuclear) events and that nuclear changes that define apoptosis (chromatin condensation and oligonucleosomal DNA fragmentation) only become manifest beyond the point-of-no-return of apoptosis, during the late degradation phase. It appears that one obligatory event of the apoptotic cascade involves a characteristic change in mitochondrial function, namely the so-called mitochondrial permeability transition. Permeability transition leading to disruption of the mitochondrial transmembrane potential precedes nuclear and plasma membrane features of apoptosis. Induction of permeability transition in cells suffices to cause the full-blown picture of apoptosis. In vitro induction of permeability transition in isolated mitochondria provokes the release of a factor capable

Who reads The cell biology of apoptosis: Evidence for the implication of mitochondria?

Author

S. A. Susin; N. Zamzami; G. Kroemer

Publisher

Springer; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC (ISSN 1360-8185)

Published

1996

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)