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Can I read Efficacy and Safety of Ibuprofen Plus Paracetamol in a Fixed-Dose Combination for Acute Postoperative Pain in Adults: Meta-Analysis and a Trial Sequential Analysis on EtoBox?
Efficacy and Safety of Ibuprofen Plus Paracetamol in a Fixed-Dose Combination for Acute Postoperative Pain in Adults: Meta-Analysis and a Trial Sequential Analysis by Dina Abushanab; Daoud Al-Badriyeh is a Medicine article available to read on EtoBox.
What is Efficacy and Safety of Ibuprofen Plus Paracetamol in a Fixed-Dose Combination for Acute Postoperative Pain in Adults: Meta-Analysis and a Trial Sequential Analysis about?
## Background: Ibuprofen and paracetamol (acetaminophen) are very commonly used for analgesia and pain. in 2020, the us fda gave its first approval of a fixed-dose combination (fdc) of the two drugs in the same tablet for postoperative pain. there has been no quantitative, summative analysis of the fdc effect size measures against postoperative pain in adults. similar analyses exist, but only in pediatric patients. ## Objective: This was the first meta-analysis to compare the efficacy and safety outcomes of the ibuprofen/paracetamol fdc against placebo, administered postoperatively, for moderate to severe pain relief in adults. ## Methods: The medline, embase, and cochrane central databases, in addition to the grey literature, were searched for clinical trials until april 2020, to identify comparative literature studies of the ibuprofen/paracetamol fdc in acute postoperative pain in adults. no restrictions on doses, formulations (oral, intravenous), and underlying type of surgery were applied. independent reviewers performed the study selection, data extraction, and the risk-of-bias and quality-of-evidence assessments based on the cochrane criteria. the outcome measures of interest
Who reads Efficacy and Safety of Ibuprofen Plus Paracetamol in a Fixed-Dose Combination for Acute Postoperative Pain in Adults: Meta-Analysis and a Trial Sequential Analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dina Abushanab; Daoud Al-Badriyeh
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)