Can I read HLA‐DRB1\*0402 haplotypes without DQB1\*0302 in Venezuelan patients with pemphigus vulgaris on EtoBox?

HLA‐DRB1\*0402 haplotypes without DQB1\*0302 in Venezuelan patients with pemphigus vulgaris by A. M. Sáenz‐Cantele; M. Fernández‐Mestre; S. Montagnani; A. Calebotta; O. Balbas; Z. Layrisse is a Immunology and Microbiology article available to read on EtoBox.

What is HLA‐DRB1\*0402 haplotypes without DQB1\*0302 in Venezuelan patients with pemphigus vulgaris about?

## Abstract The two basic forms of autoimmune intraepidermal blistering diseases, pemphigus vulgaris (PV) and pemphigus foliaceus (PF), affect different layers of the skin, have different symptoms and target different antigens. We have defined human leukocyte antigen (HLA)‐DRB1‐DQB1 alleles and haplotypes in a case–control study of 66 non‐Jewish patients attending a public reference Hospital over the past 10 years. The control group consisted of 101 matched individuals tested also by medium to high‐resolution polymerase chain reaction‐sequence‐specific oligonucleotide with primers and probes from the 12th and 13th International Histocompatibility Workshop. Patients and controls were descendants of three‐generation individuals born in the country. Among the patients, 49 had PV, 50% showed predominantly mucosal involvement, 50% showed predominantly the cutaneous clinical phenotype and 17 had PF. Statistically significant HLA‐DR frequency differences between patients with PV and controls were found only for DRB1\*0402 and DRB1\*1401 [odds ratio (OR) = 27.22, confidence interval (CI) 94.7–7.82, __P__= 1.1 × 10^−14^ and OR = 46.56, CI 801.4–2.70 __P__= 7.5 × 10^−6^, respectively]. Both

Who reads HLA‐DRB1\*0402 haplotypes without DQB1\*0302 in Venezuelan patients with pemphigus vulgaris?

Author

A. M. Sáenz‐Cantele; M. Fernández‐Mestre; S. Montagnani; A. Calebotta; O. Balbas; Z. Layrisse

Publisher

Wiley

Published

2007

Language

EN

Field

Immunology and Microbiology (Life Sciences)