Opening book details…
Can I read Presynaptic Evidence for Zinc Release at the Mossy Fiber Synapse of Rat Hippocampus on EtoBox?
Presynaptic Evidence for Zinc Release at the Mossy Fiber Synapse of Rat Hippocampus by Joshua K. Ketterman; Yang V. Li is a Neuroscience article available to read on EtoBox.
What is Presynaptic Evidence for Zinc Release at the Mossy Fiber Synapse of Rat Hippocampus about?
## Abstract Vesicular zinc (Zn^2+^) is found in a subset of glutamatergic nerve terminals throughout the mammalian forebrain and is colocalized with glutamate. Despite well‐documented neuromodulatory roles, exocytosis of endogenous Zn^2+^ from presynaptic terminals has never been directly demonstrated, because existing studies have measured elevated Zn^2+^ concentrations by examining the perfusate. Thus, the specific origin of synaptic Zn^2+^ remains a controversial subject. Here, we describe synaptic Zn^2+^ trafficking between cellular compartments at hippocampal mossy fiber synapses by using the fluorescent indicator Zinpyr‐1 to label the hippocampal mossy fiber boutons. We determined endogenous Zn^2+^ exocytosis by direct observation of vesicular Zn^2+^ as decreasing fluorescence intensity from presynaptic axonal boutons in the stratum lucidum of CA3 during neural activities induced by the stimulation of membrane depolarization. This presynaptic fluorescence gradually returned to a level near baseline after the withdrawal of moderate stimulation, indicating an endogenous mechanism to replenish vesicular Zn^2+^. The exocytosis of the synaptic Zn^2+^ was also dependent on extracel
Who reads Presynaptic Evidence for Zinc Release at the Mossy Fiber Synapse of Rat Hippocampus?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Joshua K. Ketterman; Yang V. Li
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2007
- Language
- EN
- Field
- Neuroscience (Life Sciences)