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Infantile Takayasu: clinical features and long-term outcome by Adi Miller-Barmak; Flavio Sztajnbok; Zeynep Balik; Arturo Borzutzky; Leslie A Fogel; Ofra Goldzweig; Seza Ozen; Yonatan Butbul Aviel is a Medicine article available to read on EtoBox.

What is Infantile Takayasu: clinical features and long-term outcome about?

## Abstract ## Objectives Takayasu arteritis (TAK) is a large-vessel vasculitis rarely reported in children and infants. Most articles on paediatric TAK have not focused on infants. We present the largest case series of infantile TAK, aiming to identify its demographic and clinical characteristics and compare them with existing data on older children. ## Methods We conducted an international multicentre retrospective cohort study. Epidemiological and clinical data were collected from patients’ charts from six rheumatology centres. All patients met both the EULAR/PReS 2008 criteria and the 1990 ACR/EULAR criteria and were diagnosed with TAK at age <5 years. ## Results Twelve patients were included (50% female). Median age of symptom onset was 11 months, with a diagnostic delay of 4 months. The most common symptoms at presentation were hypertension, blood pressure differences between limbs, and fever. The most commonly involved arteries were the abdominal aorta and renal artery. Medications included steroids, conventional and biologic DMARDs, and other immunosuppressive therapies. Half of the patients received biologic agents, of which infliximab had the highest complete remission ra

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Author

Adi Miller-Barmak; Flavio Sztajnbok; Zeynep Balik; Arturo Borzutzky; Leslie A Fogel; Ofra Goldzweig; Seza Ozen; Yonatan Butbul Aviel

Publisher

Oxford University Press (OUP)

Published

2022

Language

EN

Field

Medicine (Health Sciences)