Can I read Role of BicDR in bristle shaft construction, tracheal development, and support of BicD functions on EtoBox?

Role of BicDR in bristle shaft construction, tracheal development, and support of BicD functions by Aleksandra Jejina; Yeniffer Ayala; Greco Hernández; Beat Suter is a scholarly article available to read on EtoBox.

What is Role of BicDR in bristle shaft construction, tracheal development, and support of BicD functions about?

Cell polarization requires asymmetric localization of numerous mRNAs, proteins, and organelles. The movement of cargo towards the minus end of microtubules mostly depends on cytoplasmic dynein motors, which function as multiprotein complexes. In the dynein/dynactin/Bicaudal-D (DDB) transport machinery, Bicaudal-D (BicD) links the cargo to the motor. Here we focus on the role of __BicD-related__ (__BicDR__) and its contribution to microtubule-dependent transport processes. __Drosophila BicDR__ is required for the normal development of bristles and dorsal trunk tracheae. Together with __BicD,__ it contributes to the organization and stability of the actin cytoskeleton in the not-yet-chitinized bristle shaft and the localization of Spn-F and Rab6 at the distal tip. We show that __BicDR__ supports the function of __BicD__ in bristle development and our results suggest that BicDR transports cargo more locally whereas BicD is more responsible for delivering functional cargo over the long distance to the distal tip. We identified the proteins that interact with BicDR and appear to be BicDR cargo in embryonic tissues. For one of them, EF1γ, we showed that __EF1γ__ genetically interacts wit

Author

Aleksandra Jejina; Yeniffer Ayala; Greco Hernández; Beat Suter

Publisher

Cold Spring Harbor Laboratory

Published

2023

Language

EN