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2-Naphthol-pyrazole conjugates as substrates in the Mannich reaction by Gheorghe Roman is a Chemistry article available to read on EtoBox.
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## Abstract Several novel 2-naphthol-pyrazole conjugates have been synthesized through the __O__-alkylation of 1-[(3,5-dimethyl-1__H__-pyrazol-1-yl)methyl]naphthalen-2-ol with methyl iodide, benzyl chloride, methyl bromoacetate and __N__-benzyl-2-bromoacetamide. The aminomethylation of these 2-naphthol-pyrazole conjugates has been examined employing the classical conditions for the Mannich reaction, and also by using __N__,__N__-dimethylmethyleneiminium chloride as preformed aminomethylating reagent. In both situations, aminomethylation of these substrates occurred at __C__-4 of the pyrazole ring. The bifunctional substrate 1-[(3,5-dimethyl-1__H__-pyrazol-1-yl)methyl]naphthalen-2-ol has been chemoselectively aminomethylated in the pyrazole ring using the same preformed aminomethylating reagent.
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- Author
- Gheorghe Roman
- Publisher
- Walter de Gruyter GmbH
- Published
- 2018
- Language
- EN
- Field
- Chemistry (Physical Sciences)