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Can I read Efficacy and Safety of Tigecycline Versus Levofloxacin for Community-acquired Pneumonia on EtoBox?
Efficacy and Safety of Tigecycline Versus Levofloxacin for Community-acquired Pneumonia by Cristina Tanaseanu; Slobodan Milutinovic; Petre I Calistru; Janos Strausz; Marius Zolubas; Valeriy Chernyak; Nathalie Dartois; Nathalie Castaing; Hassan Gandjini; C Angel Cooper; the 313 Study Group is a Medicine article available to read on EtoBox.
What is Efficacy and Safety of Tigecycline Versus Levofloxacin for Community-acquired Pneumonia about?
## Background: Tigecycline, an expanded broad-spectrum glycylcycline, exhibits in vitro activity against many common pathogens associated with community-acquired pneumonia (cap), as well as penetration into lung tissues that suggests effectiveness in hospitalized cap patients. the aim of the present study was to compare the efficacy and safety of intravenous (iv) tigecycline with iv levofloxacin in hospitalized adults with cap. ## Methods: In this prospective, double-blind, non-inferiority phase 3 trial, eligible patients with a clinical diagnosis of cap supported by radiographic evidence were stratified by fine pneumonia severity index and randomized to tigecycline or levofloxacin for 7-14 days of therapy. co-primary efficacy endpoints were clinical response in the clinically evaluable (ce) and clinical modified intent-to-treat (c-mitt) populations at test-of-cure (day 10-21 post-therapy). ## Results: Of the 428 patients who received at least one dose of study drug, 79% had cap of mild-moderate severity according to their fine score. clinical cure rates for the ce population were 88.9% for tigecycline and 85.3% for levofloxacin. corresponding c-mitt population rates were 83.7% and
Who reads Efficacy and Safety of Tigecycline Versus Levofloxacin for Community-acquired Pneumonia?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Cristina Tanaseanu; Slobodan Milutinovic; Petre I Calistru; Janos Strausz; Marius Zolubas; Valeriy Chernyak; Nathalie Dartois; Nathalie Castaing; Hassan Gandjini; C Angel Cooper; the 313 Study Group
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2466)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)