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Non-A, non-b hepatitis in persistent carriers of hepatitis b virus by K. N. Tsiquaye; G. Tovey; H. Kessler; Shanlian Hu; Xiao-Zhen Lu; A. J. Zuckerman; J. Craske; B. Portmann; R. Williams is a Medicine article available to read on EtoBox.

What is Non-A, non-b hepatitis in persistent carriers of hepatitis b virus about?

There are reports in the literature that infection with hepatitis A virus in hepatitis B carriers can result in resolution of the carrier state. In an attempt to induce clearance of the carrier state of hepatitis B virus in two persistently infected chimpanzees, the chimpanzees were infused with documented non-A, non-B infectious material. Biochemical and histopathological evidence of hepatitis was accompanied by the unique abnormalities of endoplasmic reticulum associated with non-A, non-B hepatitis in the chimpanzees. Elevation of alanine aminotransferase was accompanied by fourfold reduction in one chimpanzee and sixfold reduction in the other in the plasma levels of HBV-associated DNA polymerase activity and simultaneously by twofold reduction in the concentration of hepatitis B surface antigen in both chimpanzees. A mediator may account for these changes in markers of hepatitis B virus infection, and this mechanism may also explain the occurrence of spontaneous regression in some persistently infected carriers. The significance of transient red cell anaemia in non-A, non-B hepatitis, which was observed in one of the chimpanzees, is yet to be established.

Who reads Non-A, non-b hepatitis in persistent carriers of hepatitis b virus?

Author

K. N. Tsiquaye; G. Tovey; H. Kessler; Shanlian Hu; Xiao-Zhen Lu; A. J. Zuckerman; J. Craske; B. Portmann; R. Williams

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

1982

Language

EN

Field

Medicine (Health Sciences)