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RAF1-HSP90-CDC37 Complex Structure by KarenZhang is a document available to read on EtoBox.
The study presents the cryo-EM structure of the RAF1-HSP90-CDC37 complex, revealing how RAF1 regulation occurs through its folding and interactions with these proteins. Disruption of the complex leads to reduced RAF1 levels and impaired cellular proliferation, suggesting a potential therapeutic strategy for Kras/tp53-driven tumors. The findings highlight the unique role of CDC37 in distinguishing between RAF family members and the implications for targeting RAF1 in cancer treatment.
- Author
- KarenZhang
- Language
- EN