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Can I read Polyamines with N -(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents on EtoBox?
Polyamines with N -(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents by Zhili Li; Michael W Fennie; Bruce Ganem; Matthew T Hancock; Muris Kobašlija; Donna Rattendi; Cyrus J Bacchi; Mary C O'Sullivan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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AbstractÐSeveral N-(3-phenylpropyl)-substituted spermidine and spermine derivatives were prepared and found to be potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase (seven compounds with K i values <5 mM are described). The most eective inhibitor studied was compound 12 with a K i value of 0.151 mM. Six of the compounds described are also eective trypanocides with IC 50 values <1 mM.
Who reads Polyamines with N -(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zhili Li; Michael W Fennie; Bruce Ganem; Matthew T Hancock; Muris Kobašlija; Donna Rattendi; Cyrus J Bacchi; Mary C O'Sullivan
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)