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Prevalence of Helicobacter pylori in patients with gastroesophageal reflux disease does not differ from a general population. The bacteria are present neither in normal epithelium nor in epithelium changed by inflammation because under normal conditions no gastric epithelium is found in esophagus. The increased prevalence of gastroesophageal reflux disease during recent years is associated with a decrease of Helicobacter pylori infection leading to speculations that Helicobacter pylori might be beneficial. The gastric inflammation caused by Helicobacter pylori infection decreases a gastric acid secretion that may explain why the intensity of reflux is not so intense and severe esophagitis does not occur. Results of epidemiologic studies differ, some of them show a protective effect against esophageal reflux disease and others show that the effect is not clinically relevant. The presence of Helicobacter pylori has no effect on percentage of relapses of the reflux esophagitis after a short-term treatment with omeprazol. Patients with duodenal and gastric ulcer undergoing an eradication therapy of Helicobacter pylori infection do not have a higher incidence of reflux esophagitis. Infl

Author

MUDr. Karel Lukáš CSc

Published

2006

Language

CS