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Aberrant myeloid antigen co-expression is correlated with high percentages of CD34-positive cells among blasts of acute lymphoblastic leukemia patients: an Indian tertiary care center perspective by Rahul Kumar Sharma; Abhishek Purohit; Venkatesan Somasundaram; Pravas Chandra Mishra; Mrinalini Kotru; Ravi Ranjan; Sunil Kumar; Sudha Sazawal; Hara Prasad Pati; Seema Tyagi; Renu Saxena is a Medicine article available to read on EtoBox.
What is Aberrant myeloid antigen co-expression is correlated with high percentages of CD34-positive cells among blasts of acute lymphoblastic leukemia patients: an Indian tertiary care center perspective about?
## Background Aberrant myeloid antigen (MA) co-expression and high expression of CD34 antigen on the blasts of acute lymphoblastic leukemia (ALL) patients are independently reported to have a role in pathogenesis and prognosis. This study was conducted to determine whether these two parameters are related. ## Methods A total of 204 cases of ALL were included in an analysis of blast immunophenotypic data. CD34 expression was categorized as low when less than 50% of blasts were CD34-positive (CD34^low^) and as high when 50% or more were CD34-positive (CD34^high^). ## Results Of 204 cases of ALL, 163 and 41 were of B-cell origin (B-ALL) and T-cell origin (T-ALL), respectively. Of all cases, 132 (64.7%) showed co-expression of MA and among these, 101 (76.51%) were CD34^high^, while the remaining 31 (23.48%) were CD34^low^. Of 72 cases without MA co-expression, 25 (34.72%) were CD34^high^ and 47 (67.25%) were CD34^low^. Furthermore, of 163 cases of B-ALL, 111 showed co-expression of MA and 84 of these were CD34^high^. Of 52 cases of B-ALL without MA expression, 22 were CD34^high^. Among 41 cases of T-ALL, 21 co-expressed MA, 17 of which were CD34^high^. Moreover, all 20 cases of T-ALL w
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- Author
- Rahul Kumar Sharma; Abhishek Purohit; Venkatesan Somasundaram; Pravas Chandra Mishra; Mrinalini Kotru; Ravi Ranjan; Sunil Kumar; Sudha Sazawal; Hara Prasad Pati; Seema Tyagi; Renu Saxena
- Publisher
- Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis (KAMJE); Korean Society of Hematology; Seoul: Korean Society of Hematology; Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; The Korean Society of Hematology (ISSN 2287-979X)
- Published
- 2014
- Language
- EN
- Field
- Medicine (Health Sciences)