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Can I read Synthesis and Evaluation of Prodrugs for Anti-angiogenic Pyrrolylmethylidenyl Oxindoles on EtoBox?
Synthesis and Evaluation of Prodrugs for Anti-angiogenic Pyrrolylmethylidenyl Oxindoles by Lesley Maskell; Emilie A. Blanche; Marie A. Colucci; Jacqueline L. Whatmore; Christopher J. Moody is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and Evaluation of Prodrugs for Anti-angiogenic Pyrrolylmethylidenyl Oxindoles about?
Potential prodrugs of inhibitors of VEGF-induced angiogenesis have been investigated. The prodrug systems studied were the 4-nitrobenzyl, 2-nitrophenylacetyl and 3-methyl-3-(3,6-dimethylbenzo-1,4-quinon-2-yl)butanoyl groups, readily attached to acidic OH or NH groups in drug molecules, and released upon bioreductive activation. The anti-angiogenic compounds studied were the pyrrolylmethylidenyl oxindole SU5416 (semaxanib) and its novel 6-hydroxy derivative. The potentially pro-anti-angiogenic compounds were assayed for their ability to block VEGF-induced angiogenesis in HUVECS in comparison to the free agents.
Who reads Synthesis and Evaluation of Prodrugs for Anti-angiogenic Pyrrolylmethylidenyl Oxindoles?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lesley Maskell; Emilie A. Blanche; Marie A. Colucci; Jacqueline L. Whatmore; Christopher J. Moody
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)