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SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein by Andrew D. Chesney; Buddhadev Maiti; Ulrich H. E. Hansmann is a Physics and Astronomy article available to read on EtoBox.

What is SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein about?

Parkinson’s disease is accompanied by the presence of amyloids in the brain that are formed of α-synuclein chains. The correlation between COVID-19 and the onset of Parkinson’s disease led to the idea that amyloidogenic segments in SARS-COV-2 proteins can induce aggregation of α-synuclein. Using molecular dynamic simulations, we show that the fragment FKNIDGYFKI of the spike protein, which is unique for SARS-COV-2, preferentially shifts the ensemble of α-synuclein monomer toward rod-like fibril seeding conformations and, at the same time, differentially stabilizes this polymorph over the competing twister-like structure. Our results are compared with earlier work relying on a different protein fragment that is not specific for SARS-COV-2.

Who reads SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein?

Author

Andrew D. Chesney; Buddhadev Maiti; Ulrich H. E. Hansmann

Publisher

AIP Publishing

Published

2023

Language

EN

Field

Physics and Astronomy (Physical Sciences)