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Topical Vasodilators in Microsurgery: What Is the Evidence? by Jacob Rinkinen; Eric Halvorson is a Medicine article available to read on EtoBox.

What is Topical Vasodilators in Microsurgery: What Is the Evidence? about?

Topical vasodilators are frequently used during free tissue transfer to prevent and treat vasospasm and microvascular thrombosis. A variety of agents have been studied and are available, yet most microsurgeons select an agent based on anecdotal evidence or personal training. Our aim was to review the literature on topical vasodilators so microsurgeons can make more informed decisions about which agent to use. A systemic review of the literature was performed on PubMed, EMBASE, and Google Scholar using keywords "topical vasodilator," "antispasmodic," "vasospasm," "free flaps," and "microsurgery." Studies were included if they provided a comparative quantitative assessment of topical vasodilators and were written in English. In vitro, in vivo and clinical studies were included. A total of 15 studies were identified and included in our analysis. The three most common classes of topical vasodilator include local anesthetics, phosphodiesterase inhibitors, and calcium channel blockers (CCBs). Of the most commonly used topical vasodilators, CCBs (nifedipine and verapamil) were most effective followed by papaverine and lidocaine. The most effective topical vasodilators appear to be CCBs

Who reads Topical Vasodilators in Microsurgery: What Is the Evidence??

Author

Jacob Rinkinen; Eric Halvorson

Published

2016

Language

EN

Field

Medicine (Health Sciences)