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The Polymerase Chain Reaction by Kary B. Mullis, François Ferré, Richard A. Gibbs, editors is a book available to read on EtoBox.
What is The Polymerase Chain Reaction about?
James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases.'It has not escaped our notice,'Francis wrote,'that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material.'By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two chains
- Author
- Kary B. Mullis, François Ferré, Richard A. Gibbs, editors
- Publisher
- Birkhäuser Boston
- Published
- 2012
- Language
- EN
- ISBN
- 9780817636074
- Subjects
- Medical, Science, Biology
Other editions & translations
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