Can I read Role of Extracellular Signal-Regulated Protein Kinases 1 and 2 in Oligodendroglial Process Extension on EtoBox?
Role of Extracellular Signal-Regulated Protein Kinases 1 and 2 in Oligodendroglial Process Extension by Rochelle L. Stariha; Seiji Kikuchi; Yaw L. Siow; Steven L. Pelech; Myong Kim; Seung U. Kim is a Neuroscience article available to read on EtoBox.
What is Role of Extracellular Signal-Regulated Protein Kinases 1 and 2 in Oligodendroglial Process Extension about?
Abstract: The relationship between extracellular signal‐regulated protein kinase (ERK) activation and process extension in cultured bovine oligodendrocytes (OLGs) was investigated. Process extension was induced through the exposure of cultured OLGs to phorbol 12‐myristate 13‐acetate (PMA), an activator of protein kinase C (PKC), for various intervals. During the isolation of these OLGs from bovine brain, the original processes were lost. Therefore, any reinitiation of process extension via PMA stimulation was easily discernible through morphological monitoring. It was found that exposure of OLGs to PMA for 10 min was enough to induce OLG process extension 24–72 h later. Furthermore, this extension was still evident at least 1 week after the initial PMA stimulation, indicating that OLGs do not need continuous PKC activation to sustain process extension. Control and PMA‐stimulated OLGs were also subjected to immunocytochemistry using an anti‐ERK antibody selective for the mitogen‐activated protein kinases p42 Erk2 (ERK2) and p44 Erk1 (ERK1) isoforms. ERK immunoreactivity in the nucleus was evident after PMA stimulation of OLGs but not in control OLGs. In parallel experiments, the con
Who reads Role of Extracellular Signal-Regulated Protein Kinases 1 and 2 in Oligodendroglial Process Extension?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Rochelle L. Stariha; Seiji Kikuchi; Yaw L. Siow; Steven L. Pelech; Myong Kim; Seung U. Kim
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 1997
- Language
- EN
- Field
- Neuroscience (Life Sciences)