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Adenosine A~2a~ Receptor‐Mediated Modulation of Striatal Acetylcholine Release In Vivo by Masako Kurokawa; Kumiko Koga; Hiroshi Kase; Joji Nakamura; Yoshihisa Kuwana is a Neuroscience article available to read on EtoBox.

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Abstract: To determine the functions of striatal adenosine A~2a~ receptors in vivo, the effects of a selective agonist, 2‐[4‐(2‐carboxyethyl)phenethylamino]‐5′‐__N__‐ethylcarboxamidoadenosine hydrochloride (CGS 21680), and an antagonist, (__E__)‐8‐(3,4‐dimethoxystyryl)‐1,3‐dipropyl‐7‐methylxanthine (KF17837), on acetylcholine release were investigated in the striatum of awake freely moving rats using microdialysis. Intracerebroventricular injection of CGS 21680 (10 μg) increased acetylcholine release in striatum and KF17837 (30 mg/kg p.o.) antagonized the CGS 21680‐induced acetylcholine elevation. To investigate the contribution of dopaminergic and GABAergic neurons on A~2a~ receptor‐mediated acetylcholine release, the effects of CGS 21680 were studied by using dopamine‐depleted rats in the presence or absence of GABA antagonists. In the dopamine‐depleted striatum, the intrastriatal application of CGS 21680 (0.3–30 μ__M__) increased extracellular acetylcholine, which was significantly greater than that in normal striatum. The CGS 21680‐induced elevation of acetylcholine release was still observed in the presence of GABA antagonists bicuculline (30 μ__M__) and 2‐hydroxysaclofen (100

Who reads Adenosine A~2a~ Receptor‐Mediated Modulation of Striatal Acetylcholine Release In Vivo?

Author

Masako Kurokawa; Kumiko Koga; Hiroshi Kase; Joji Nakamura; Yoshihisa Kuwana

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)

Published

1996

Language

EN

Field

Neuroscience (Life Sciences)