Can I read Trends in new drug interactions for pharmaceutical products in Japan on EtoBox?

Trends in new drug interactions for pharmaceutical products in Japan by Naoko Yoshida; Akito Yamada; Yasuhiko Mimura; Junichi Kawakami; Isao Adachi is a Medicine article available to read on EtoBox.

What is Trends in new drug interactions for pharmaceutical products in Japan about?

## Abstract ## Purpose The aim of the present study was to elucidate the trends in drug interactions for pharmaceutical products in Japan by examining safety profile updates. ## Methods All 12 422 prescription drugs currently on the Japanese market were included in the study. Revisions to their product information (or package insert: PI) were investigated from January 2000 to December 2003. The publication ‘Drug Safety Update,’ which is a summary of the revisions made to the precautions in PIs and is issued by The Society of Japanese Pharmacopoeia and The Federation of Pharmaceutical Manufacturers' Associations of Japan under the supervision of the Ministry of Health, Labour and Welfare (MHLW), was used as a data source. The revised drug interactions were categorized according to measures, mechanisms, and evidence from published references. ## Results and Conclusions The results revealed 426 new interactions, including 75 contraindicative combinations, during the survey period. About 45% and 27% of the new interactions involved metabolic and pharmacological processes, respectively, with metabolic interactions involving cytochrome P450 3A4 being the dominant reason for the revision

Who reads Trends in new drug interactions for pharmaceutical products in Japan?

Author

Naoko Yoshida; Akito Yamada; Yasuhiko Mimura; Junichi Kawakami; Isao Adachi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-8569)

Published

2005

Language

EN

Field

Medicine (Health Sciences)