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Can I read Total Synthesis of the Chlorinated Pentacyclic Indole Alkaloid (+)-Ambiguine G on EtoBox?
Total Synthesis of the Chlorinated Pentacyclic Indole Alkaloid (+)-Ambiguine G by Lingbowei Hu; Viresh H. Rawal is a Chemistry article available to read on EtoBox.
What is Total Synthesis of the Chlorinated Pentacyclic Indole Alkaloid (+)-Ambiguine G about?
Reported herein is the total synthesis of (+)-ambiguine G, the first member of the chlorinated pentacyclic ambiguines to yield to chemical synthesis. The synthesis is accomplished through a convergent strategy that proceeds in 10 steps from ()-carvone oxide. Pivotal to the concise route is the successful realization of a [4+3] cycloaddition that conjoins two easily synthesized components of the carbon framework of the natural product. Also featured in the synthesis is the efficient, diastereoselective construction of a key vinylated chloro ketone and the unprecedented, one-pot reduction-elimination-oxidation sequence that transforms an enone to an advanced hydroxylated-diene intermediate.
Who reads Total Synthesis of the Chlorinated Pentacyclic Indole Alkaloid (+)-Ambiguine G?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Lingbowei Hu; Viresh H. Rawal
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)