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Three-dimensional (3D-) reconstruction of M cells in rabbit peyer's patches: Definition of the intraepithelial compartment of the follicle-associated epithelium by Dr. Marì Regoli; Eugenio Bertelli; Chiara Borghesi; Claudio Nicoletti is a Medicine article available to read on EtoBox.

What is Three-dimensional (3D-) reconstruction of M cells in rabbit peyer's patches: Definition of the intraepithelial compartment of the follicle-associated epithelium about?

One of the major cell components of the rabbit follicle-associated epithelium is represented by the M cells. M cells are able to harbour variable amounts of immunocompetent cells inside peculiar invaginations of their basolateral cytoplasmic membrane, currently referred to as "pockets." This study provides a description of the exact spatial relationships between the M cells and the cells harboured in these so-called "pockets." Pieces of Peyer's patches, taken from the small intestine of an adult male rabbit, were treated as usual for conventional electron microscopy. Consecutive semithin and ultrathin sections were made through the entire thickness of the follicle-associated epithelium along planes parallel to the mucosal surface. Micrographs, taken from the ultrathin sections, were transposed into a software MacDraw Pro to obtain a computerized threedimensional reconstruction. Three-dimensional reconstruction of the M cells showed that the "pockets" were not formed by mere invaginations of the cytoplasmic membrane, but that they resulted from the branching of the supranuclear portion of the M cell cytoplasm around the M cell-infiltrating lymphocytes. These intrusive cells could be

Who reads Three-dimensional (3D-) reconstruction of M cells in rabbit peyer's patches: Definition of the intraepithelial compartment of the follicle-associated epithelium?

Author

Dr. Marì Regoli; Eugenio Bertelli; Chiara Borghesi; Claudio Nicoletti

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0003-276X)

Published

1995

Language

EN

Field

Medicine (Health Sciences)