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Venous refocusing for volume estimation: VERVE functional magnetic resonance imaging by Bojana Stefanovic; G. Bruce Pike is a Medicine article available to read on EtoBox.

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## Abstract A novel, noninvasive magnetic resonance imaging‐based method for measuring changes in venous cerebral blood volume (CBV~v~) is presented. Venous refocusing for volume estimation (VERVE) exploits the dependency of the spin–spin relaxation rate of deoxygenated blood on the refocusing interval. Interleaved CPMG EPI acquisitions following a train of either tightly or sparsely spaced hard refocusing pulses (every 3.7 or 30 msec, respectively) at matched echo time were used to isolate the blood signal while minimizing the intravascular blood oxygenation level dependent (BOLD) signal contribution. The technique was employed to determine the steady‐state increase in the CBV~v~ in the visual cortex (VC) in seven healthy adult volunteers during flickering checkerboard photic stimulation. A functional activation model and a set of previously collected in vitro human whole blood relaxometry data were used to evaluate the intravascular BOLD effect on the VERVE signal. The average VC venous blood volume change was estimated to be 16 ± 2%. This method has the potential to provide efficient and continuous monitoring of venous cerebral blood volume, thereby enabling further exploration

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Author

Bojana Stefanovic; G. Bruce Pike

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2005

Language

EN

Field

Medicine (Health Sciences)