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Antiphospholipid Antibodies in Sickle Cell Disease by O. Kucuk; A. Gilman-Sachs; K. Beaman; L. J. Lis; M. P. Westerman is a Medicine article available to read on EtoBox.

What is Antiphospholipid Antibodies in Sickle Cell Disease about?

Antiphospholipid antibody formation can be Induced In mice by phospholipid In a hexagonal II phase but not by phospholipid in a bllayer phase. Since sickle red cell membranes have increased hexagonal I1 phase content, we have measured serum antiphospholipid antibody levels in 25 patients with sickle cell disease to determine whether anti-phospholipid antibody may similarly be Induced in these patients. Seventeen of the 25 patients (68%) had Increased levels of antiphospholipid antibodies. Eleven patients (65%) had IgG and six each (35%) had IgM and IgA isotypes. Antiphosphatidylethanolamine, antiphosphatidylserine, antiphosphatidyllnositol, and antlphosphatidic acid were the most frequently increased antibodies. The finding of increased antiphospholipid antibodies In these patients is compatible with the concept that antiphospholipid antibody formation is associated with structural changes in the red cell membrane and that such structural changes occur in the red cells of patients with sickle ceii disease.

Who reads Antiphospholipid Antibodies in Sickle Cell Disease?

Author

O. Kucuk; A. Gilman-Sachs; K. Beaman; L. J. Lis; M. P. Westerman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)

Published

1993

Language

EN

Field

Medicine (Health Sciences)