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Erosion of Biodegradable Block Copolymers Made of Poly(d,l-lactic Acid) and Poly(ethylene Glycol) by Friederike von Burkersroda; Ruxandra Gref; Achim Göpferich is a Engineering article available to read on EtoBox.

What is Erosion of Biodegradable Block Copolymers Made of Poly(d,l-lactic Acid) and Poly(ethylene Glycol) about?

## Biodegradable block copolymers made of poly(ethylene glycol) monomethylether (Me.PEG) and poly(o,L-lactic acid) (PLA) were investigated for their erosion properties. Wide angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC) investigations prior to erosion revealed that despite the low content of crystallizable Me.PEG of lo%, Me.PEGsPLA45 is a partially crystalline polymer. The erosion of the polymer was investigated using cylindrical polymer matrix discs with a diameter of 8mm and a height of 1.5mm. WAXD and DSC spectra obtained from eroded polymer matrix discs suggest that both polymer blocks separate completely during erosion. The crystallinity of Me.PEG5-PLA45 was found to increase during erosion, which is probably due to the improved mobility of Me.PEG inside the polymer with a progressive degree of degradation. The erosion kinetics were found to be similar to that of PLA or poly(lactic-co-glycolic acid). During erosion the polymer matrix weight of dried samples remains constant for 11 weeks after which erosion sets in rapidly. From this observation one can conclude that the impact of the relatively small Me.PEG chains on Me.PEG5-PLA45 erosion is not pr

Who reads Erosion of Biodegradable Block Copolymers Made of Poly(d,l-lactic Acid) and Poly(ethylene Glycol)?

Author

Friederike von Burkersroda; Ruxandra Gref; Achim Göpferich

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

1997

Language

EN

Field

Engineering (Physical Sciences)