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Biselyngbyaside, Isolated from Marine Cyanobacteria, Inhibits Osteoclastogenesis and Induces Apoptosis in Mature Osteoclasts by Takayuki Yonezawa; Naomi Mase; Hiroaki Sasaki; Toshiaki Teruya; Shin-ichi Hasegawa; Byung-Yoon Cha; Kazumi Yagasaki; Kiyotake Suenaga; Kazuo Nagai; Je-Tae Woo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Biselyngbyaside, Isolated from Marine Cyanobacteria, Inhibits Osteoclastogenesis and Induces Apoptosis in Mature Osteoclasts about?
## Abstract The mass and function of bones depend on the maintenance of a complicated balance between osteoclast‐mediated bone resorption and osteoblast‐mediated bone formation. An inhibitor of osteoclast differentiation and/or function is expected to be useful for treatment of bone lytic diseases such as osteoporosis, rheumatoid arthritis, and tumor metastasis into bone. Biselyngbyaside is a recently isolated macrolide compound from marine cyanobacteria __Lyngbya__ sp. that shows wide‐spectrum cytotoxicity toward human tumor cell lines. In this study, we investigated the effects of biselyngbyaside on osteoclast differentiation and function. Biselyngbyaside inhibited receptor activator of nuclear factor‐κB ligand (RANKL)‐induced osteoclastogenesis in mouse monocytic RAW264 cells and primary bone marrow‐derived macrophages at a low concentration. Similarly, biselyngbyaside suppressed osteoblastic cell‐mediated osteoclast differentiation in cocultures. In the RANKL‐induced signaling pathway, biselyngbyaside inhibited the expression of c‐Fos and NFATc1, which are important transcription factors in osteoclast differentiation. In mature osteoclasts, biselyngbyaside decreased resorption‐
Who reads Biselyngbyaside, Isolated from Marine Cyanobacteria, Inhibits Osteoclastogenesis and Induces Apoptosis in Mature Osteoclasts?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Takayuki Yonezawa; Naomi Mase; Hiroaki Sasaki; Toshiaki Teruya; Shin-ichi Hasegawa; Byung-Yoon Cha; Kazumi Yagasaki; Kiyotake Suenaga; Kazuo Nagai; Je-Tae Woo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 2012
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)