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Two Possible Mechanisms Underlying Nitrate Tolerance In Monkey Coronary Arteries by Tomoko Omura; Tetsuya Matsumoto; Ichiro Nakae; Masayuki Takahashi; Masahiko Kinoshita is a Medicine article available to read on EtoBox.

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## SUMMARY 1. Previous studies using isolated arteries have demonstrated cross‐tolerance between nitric oxide (NO) donors such as nitroglycerin (NTG) and sodium nitroprusside (SNP). However, it remains unclear whether the vasorelaxing effect of atrial natriuretic peptide (ANP), an activator of particulate guanylate cyclase, is affected by treatment with NO donors. To investigate the cross‐tolerance and interactions between NTG and ANP in coronary vasorelaxant responses, we used two models of monkey coronary arterial strips (__Macaca fuscata__). 2. In one model, which was induced by a 1 h treatment with 4.4 × 10^–4^ mol/L NTG followed by washout of the agent for 1 h, the vasorelaxing effects of subsequent NTG were markedly attenuated, whereas those of ANP and NO were not affected. These findings suggest that the development of NTG tolerance is associated with a biotransformation process from NTG to NO. In the other model, which did not include washout after exposure to 3 × 10^–6^ mol/L NTG, the vasorelaxant responses to 10^–8^ mol/L ANP (31.1±5.4 __vs__ 5.1±2.1%, respectively; __P__ < 0.001), 10^–6^ mol/L NO (61.5±2.4 __vs__ 29.5±8.5%, respectively; __P__ < 0.001) and 10^–8^ mol/L S

Who reads Two Possible Mechanisms Underlying Nitrate Tolerance In Monkey Coronary Arteries?

Author

Tomoko Omura; Tetsuya Matsumoto; Ichiro Nakae; Masayuki Takahashi; Masahiko Kinoshita

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0305-1870)

Published

2001

Language

EN

Field

Medicine (Health Sciences)