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Plasma p-tau181 and p-tau217 in discriminating PART, AD and other key neuropathologies in older adults by Lei Yu; Patricia A. Boyle; Shorena Janelidze; Vladislav A. Petyuk; Tianhao Wang; David A. Bennett; Oskar Hansson; Julie A. Schneider is a Medicine article available to read on EtoBox.

What is Plasma p-tau181 and p-tau217 in discriminating PART, AD and other key neuropathologies in older adults about?

We examined whether plasma p-tau181 and p-tau217 are specific biomarkers of pathologically confirmed Alzheimer’s disease (AD). In particular, we investigated the utility of plasma p-tau for differentiating AD from primary age-related tauopathy (PART), as well as AD with mixed pathologies. Data came from 269 older adults who participated in the Religious Orders Study or the Rush Memory and Aging Project. Blood samples were collected during annual clinical evaluations. Participants died and underwent brain autopsy. P-tau181 and p-tau217 were quantified in the plasma samples proximate to death (average interval before death: 1.4 years) using Lilly-developed MSD immunoassays. Uniform neuropathologic evaluations assessed AD, PART, and other common degenerative and cerebrovascular conditions. Plasma p-tau217 was more strongly correlated with brain β-amyloid and paired helical filament tau (PHFtau) tangles than p-tau181. Both p-tau markers were associated with greater odds of AD, but p-tau217 had higher accuracy (area under the ROC curve (AUC): 0.83) than p-tau181 (AUC: 0.76). Plasma p-tau markers were almost exclusively associated with AD pathologic indices with the exception of cerebral

Who reads Plasma p-tau181 and p-tau217 in discriminating PART, AD and other key neuropathologies in older adults?

Author

Lei Yu; Patricia A. Boyle; Shorena Janelidze; Vladislav A. Petyuk; Tianhao Wang; David A. Bennett; Oskar Hansson; Julie A. Schneider

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Life Sciences)