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Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients by Solís-Vivanco, Rodolfo (author);Mondragón-Maya, Alejandra (author);Reyes-Madrigal, Francisco (author);de la Fuente-Sandoval, Camilo (author) is a Medicine article available to read on EtoBox.

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## Abstract We explored the neurophysiological activity underlying auditory novelty detection in antipsychotic-naive patients with a first episode of psychosis (FEP). Fifteen patients with a non-affective FEP and 13 healthy controls underwent an active involuntary attention task along with an EEG acquisition. Time-frequency representations of power, phase locking, and fronto-parietal connectivity were calculated. The P3a event-related potential was extracted as well. Compared to controls, the FEP group showed reduced theta phase-locking and fronto-parietal connectivity evoked by deviant stimuli. Also, the P3a amplitude was significantly reduced. Moreover, reduced theta connectivity was associated with more severe negative symptoms within the FEP group. Reduced activity (phase-locking and connectivity) of novelty-related theta oscillations, along with P3a reduction, may represent a failure to synchronize large-scale neural populations closely related to fronto-parietal attentional networks, and might be explored as a potential biomarker of disease severity in patients with emerging psychosis, given its association with negative symptoms.

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Author

Solís-Vivanco, Rodolfo (author);Mondragón-Maya, Alejandra (author);Reyes-Madrigal, Francisco (author);de la Fuente-Sandoval, Camilo (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Life Sciences)