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Pharmacological evidence for GABAergic regulation of specific behaviors in Drosophila melanogaster by Sandra M. Leal; Wendi S. Neckameyer is a Neuroscience article available to read on EtoBox.

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## Abstract We have identified several GABAergic‐modulated behaviors in __Drosophila melanogaster__ by employing a pharmacological approach to disrupt GABA transporter function __in vivo__. Systemic treatment of adult female flies with the GABA transport inhibitors DL‐2,4‐diaminobutyric acid (DABA) or R,S‐nipecotic acid (NipA), resulted in diminished locomotor activity, deficits in geotaxis, and the induction of convulsive behaviors with a secondary loss of the righting reflex. Pharmacological evidence suggested that the observed behavioral phenotypes were specific to disruption of GABA transporter function and GABAergic activity. The effects of GABA reuptake inhibitors on locomotor activity were dose dependent, pharmacologically distinct, and paralleled their known effects in mammalian systems. Recovery of normal locomotor activity and the righting reflex in DABA‐ and NipA‐treated flies was achieved by coadministration of bicuculline (BIC), a GABA receptor antagonist that supresses GABAergic activity in mammals. Recovery of these behaviors was also achieved by coadministration of gabapentin, an anticonvulsant agent that interacts with mammalian GABAergic systems. Finally, behavior

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Author

Sandra M. Leal; Wendi S. Neckameyer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3034)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)