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A Phase II trial of cisplatin and 5-fluorouracil in adenocarcinoma of the oesophagus by R.S. Steyn; R. Vijeyasingam; S.J. Darnton; M.H. Cullen; H.R. Matthews is a Agricultural and Biological Sciences article available to read on EtoBox.

What is A Phase II trial of cisplatin and 5-fluorouracil in adenocarcinoma of the oesophagus about?

The effect of brief neoadjuvant chemotherapy in patients with apparently operable adenocarcinoma of the oesophagus has been investigated. Two courses of cisplatin and 5-fluorouracil (CFu) were given, followed by evaluation of the response by barium swallow. Twenty-one of 23 patients completed both courses. Two showed a complete response and five a partial response. In only one patient was there a pathological complete response. Toxicity was mild and consisted principally of nausea and vomiting. All patients underwent surgical exploration; resection was completed in 17. There were three hospital deaths (18%). Although CFu has produced two complete responses (on barium swallow) and one complete pathological clearance of tumour, the disappointing total response rate of 7/21 (33%; 95% CI 13-53) or 7/ 23 (30%; 95% CI 12-49) leads us to believe that further Phase II trials are needed to identify more efficacious agents and regimens.

Who reads A Phase II trial of cisplatin and 5-fluorouracil in adenocarcinoma of the oesophagus?

Author

R.S. Steyn; R. Vijeyasingam; S.J. Darnton; M.H. Cullen; H.R. Matthews

Publisher

Elsevier Science; Springer; Elsevier ; Springer-Verlag; W. B. Saunders Co., Ltd.; Springer Verlag; Elsevier BV; Springer Science and Business Media LLC (ISSN 1433-2981)

Published

1998

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)