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Reovirus Uses Macropinocytosis-Mediated Entry and Fast Axonal Transport To Infect Neurons by Devinda Shameera is a document available to read on EtoBox.
This research article investigates how reovirus infects neurons, revealing that it utilizes macropinocytosis for entry, differing from the clathrin-mediated endocytosis used in non-neuronal cells. The study demonstrates that reovirus spreads retrograde along axons via dynein-mediated fast axonal transport, with disassembly and replication occurring in the neuronal soma. These findings provide insights into the mechanisms of neurotropic virus entry and transport, which could inform therapeutic strategies aga
- Author
- Devinda Shameera
- Language
- EN