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Medulloblastoma: Distinctive Histo-Molecular Correlation with Clinical Profile, Radiologic Characteristics, and Surgical Outcome by Vinayak Narayan; Harsha Sugur; Janhvi Jaiswal; H.R. Arvinda; Arimappamagan Arivazhagan; Sampath Somanna; Vani Santosh is a Medicine article available to read on EtoBox.
What is Medulloblastoma: Distinctive Histo-Molecular Correlation with Clinical Profile, Radiologic Characteristics, and Surgical Outcome about?
**__Objective:__** Medulloblastoma (MB) is a heterogenous tumor, and the prognosis is influenced by various clinical, histological, and molecular factors. The aim of the study is to determine the clinical profile and radiologic characteristics among the histo-molecular subgroups, the predictors of surgical outcome, and the pattern of relapse in pediatric and adult MB. **__Method:__** An analysis of 118 patients of MB who underwent surgical treatment at National Institute of Mental Health and Neurosciences, India, over a 7-year period (2005–2011) is presented. The clinical profile, radiologic characteristics, surgical nuances, and survival patterns are discussed. The relevant statistical analysis was done using SPSS software, version 22.0. **__Results:__** The mean age of the cohort was 12 years (12.3 ± 8.7). The primary manifestation was raised intracranial tension headache in 53 patients (44.9%), which was the predominant symptom in large cell/anaplastic (LCA)- and WNT-activated subgroups. The median preoperative Karnofsky performance score was 60 (60.6 ± 12.9). Vermian and hemispheric location of tumor was most commonly observed in non-WNT/non-SHH (groups 3 and 4; 91.7%) and SHH-
Who reads Medulloblastoma: Distinctive Histo-Molecular Correlation with Clinical Profile, Radiologic Characteristics, and Surgical Outcome?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Vinayak Narayan; Harsha Sugur; Janhvi Jaiswal; H.R. Arvinda; Arimappamagan Arivazhagan; Sampath Somanna; Vani Santosh
- Publisher
- S. Karger AG
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)