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Intrathecal IgM index correlates with a severe disease course in multiple sclerosis: Clinical and MRI results by Serkan Ozakbas; Bilge Piri Cinar; Pinar Özcelik; Hatice Baser; Gorkem Kosehasanoğullari is a Medicine article available to read on EtoBox.

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## Objectives: Intrathecally synthesized igm can be seen not only in the cerebrospinal fluid (csf) in infectious and inflammatory diseases of the central nervous system, but also in that of patients with multiple sclerosis (ms). intrathecal igm synthesis in ms seems to be correlated with an unfavorable disease course. in one cross-sectional study, intrathecal synthesis of igm (igm index) was found to be correlated with cranial magnetic resonance imaging (mri) parameters. the purpose of this study was to determine the possible relationship between the igm index and mri and clinical parameters. ## Patients and methods: Eighty-one patients with ms (58 female) undergoing lumbar puncture were included in the study. fifty-one patients had a relapsing-remitting (rr) disease course, while 30 cases were secondary progressive ms (spms). igm was detected in paired csf and serum specimens using elisa. the igm index was calculated using the formula csf igm/serum igm: csf albumin/serum albumin. igm indexes higher than 0.1 were considered "increased". all patients underwent brain and whole spinal cord mri. ## Results: The igm index was normal in 43 of the 81 patients (53.1%) and increased in 38 (

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Author

Serkan Ozakbas; Bilge Piri Cinar; Pinar Özcelik; Hatice Baser; Gorkem Kosehasanoğullari

Publisher

Elsevier BV

Published

2017

Language

EN

Field

Medicine (Health Sciences)